Département de Chimie and PROTEO, Faculté des Sciences et de Génie, Université Laval, Pavillon Alexandre-Vachon, 1045 avenue de la Médecine, Québec, QC, Canada, G1V 0A6
J. Am. Chem. Soc., 2011, 133 (17), pp 6481–6483
DOI: 10.1021/ja110336s
Publication Date (Web): March 8, 2011
Copyright © 2011 American Chemical Society
Analogues of a synthetic ion channel made from a helical peptide were used to study the mechanism of cation translocation within bilayer membranes. Derivatives bearing two, three, four, and six crown ethers used as ion relays were synthesized, and their transport abilities across lipid bilayers were measured. The results showed that the maximum distance a sodium ion is permitted to travel between two binding sites within a lipid bilayer environment is 11 Å.
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