Aptamer-Based Origami Paper Analytical Device for Electrochemical Detection of Adenosine†

1. Hong Liu¹, 
2. Dr. Yu Xiang², 
3. Prof. Yi Lu²,
4. Prof. Richard M. Crooks^1,*

Article first published online: 25 MAY 2012

DOI: 10.1002/anie.201202929

Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Paper biosensors: An origami sensor is printed on a single piece of paper, folded into a three-dimensional fluidic device, and encapsulated by thermal lamination. Aptamer is trapped in the fluidic channel, where it binds to the target and releases an enzyme to generate a signal. The device is read out using a digital multimeter.